Antisense Homology Boxes in Proteins

Amphiphilic peptides approximately fteen amino acids in length and their corresponding antisense peptides exist within protein molecules. These regions (termed antisense homology boxes) are separated by approximately fty amino acids. Since many sense-antisense peptide pairs have been reported to recognize and bind to each other, antisense homology boxes may be involved in folding, chaperoning and oligomer formation of proteins. The nding that cc 70 per cent of the antisense homology box derived peptides from C5a receptor and human Endothelin A receptor are speci c inhibitors or agonist to their corresponding proteins indicate that these regions can have signi cant role in proteins.